ANC Workshop - Charitos Maniatis

Speaker: Christos Maniatis

Title: Multi-modal deep generative modelling for single cell multi-omics data.

Abstract:  Recent development in single cell multiomics assays offer unprecedented opportunities to explore gene regulation at a single cell resolution, providing deeper insights into the functions of diverse tissues. However, due to technical artifacts, it is often challenging to jointly analyze and integrate different modalities into a unified cell state representation. Here we demonstrate that coupling latent states of unimodal variational auto-encoders during training can produce interpretable latent representations, denoise and impute single cell multi-omics data and reveal associations between different omics layers.