ANC Workshop - Oksana Sorokina, Peggy Seriès
Tuesday, 29th November 2022
BioNAR: An Integrated Biological Network Analysis Package in Bioconductor - Oksana Sorokina
Abstract: Methods developed in social network science have been successfully applied in the biomedical domain over the past two decades. Examples include splitting biological networks into communities, to discover highly enriched complexes with specific diseases and neuronal functions. Here we present the Bioconductor package BioNAR to perform a step-by-step analysis of biological/biomedical networks with the aim of quantifying and ranking each of the network’s vertices based on network topology and clustering. When applied to PPI networks the package predicts a protein’s impact within multiple complexes, and enables the co-occurrence of meta-data, i.e., diseases and functions, to be estimated across the network and clusters, pointing towards shared/common mechanisms.
Computational approaches to post-traumatic stress disorder (PTSD) and childhood trauma (cPTSD) - Peggy Seriès
Abstract: Recently, a number of computational models have been proposed that account for PTSD symptoms in terms of impairments in predictive coding or Bayesian inference. These models can account for PTSD symptomatology, including intrusions, flashbacks and hallucinations. I will first briefly review these models.
These models have usually been developed to account for traditional/type-1 PTSD (e.g. combat related). I will discuss whether these models also apply or can be translated to the case of complex/type-2 PTSD and childhood trauma (cPTSD). The distinction between PTSD and cPTSD is important, because the disorders differ in terms of symptomatology and potential mechanisms, in particular how they relate to developmental stages, but also in terms of illness trajectory and treatment.
Ultimately, computational models of complex trauma could give us insights on the development of psychotic experiences (and perhaps mental illness in general?) across diagnostic classes.
- work with Prof Renaud Jardri (Université de Lille, CHU Lille and Inserm U-960)
Event type: Workshop
Date: Tuesday, 29th November 2022
Speaker(s): Oksana Sorokina, Peggy Seriès
Chair/Host: Hannah Jones